The second Semi-Final of “Pabandom iš naujo! 2022” was recorded on 25 January 2022, and broadcasted on 5 February 2022. Nine competing artists battled for four spots in the Grand Final.
Monika Liu, Augustė Vedrickaitė-Augustė and Rūta Loop placed in the TOP-3, while the singer of the song “Get Up” failed, receiving only six points and finishing last on the second Semi-Final. Additionally, a total of 8 974 votes were cast!
List of Jurors
 |  |  |  |  |
| IEVA NARKUTĖ | RAMŪNAS ZILNYS | GERŪTA GRINIŪTĖ | VYTAUTAS BIKUS | STANISLAV STAVITSKY-STANO |
| Singer & Songwriter | Journalist & Music Critic | TV and Radio Presenter | Composer & Producer | Singer & Songwriter |
Running Order
| DRAW | ARTIST | SONG |
| 01 | Mary Mo | “Get Up” |
| 02 | Vilija Matačiūnaitė | “Šimtas ir vienas” |
| 03 | Urtė Šilagalytė | “Running Chords” |
| 04 | Ieva Zasimauskaitė | “I’ll Be There” |
| 05 | Augustė Vedrickaitė-Augustė | “Before You’re 6ft Under” |
| 06 | Rūta Loop | “Call Me from the Cold”” |
| 07 | Titas & Benas | “Getting Through This” |
| 08 | Monika Liu | “Sentimentai” |
| 09 | Moosu X | “Love That Hurts” |
Results
| DRAW | JURY VOTE (Points) | PUBLIC VOTE (Points) | TOTAL POINTS | PLACE |
| 08 | 58 (12 PT) | 3,965 (12 PT) | 24 PT | 1 |
| 05 | 49 (10 PT) | 934 (8 PT) | 18 PT | 2 |
| 06 | 37 (8 PT) | 878 (7 PT) | 15 PT | 3 |
| 04 | 37 (8 PT) | 481 (5 PT) | 13 PT | 4 |
| 03 | 12 (2 PT) | 1,165 (10 PT) | 12 PT | 5 |
| 02 | 30 (6 PT) | 303 (3 PT) | 9 PT | 6 |
| 07 | 26 (5 PT) | 610 (4 PT) | 9 PT | 7 |
| 09 | 16 (3 PT) | 637 (6 PT) | 9 PT | 8 |
| 01 | 20 (4 PT) | 301 (2 PT) | 6 PT | 9 |